The Home For Water is accessible by taxi and the M23 or M14 crosstown buses.

The nearest subway is the C and E at 23rd Street and Eighth Avenue, then pick up the M23 and walk 2-3 long blocks west.

Another option is to take the A, C, E to 14th Street or the L train to Eighth Avenue, walk to the river, then follow the walking/riding/running path along the river north.
Bus: M14, M23

Subway:

               

To 14th or 23rd St.
Transfer to west bound
M14 or M23 bus.